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A low background Raman probe for optical biopsy of brain tissue

Stevens, Oliver A. C., Hutchings, Joanne, Gray, William Peter and Day, John C. 2014. A low background Raman probe for optical biopsy of brain tissue. Presented at: Biomedical Vibrational Spectroscopy VI: Advances in Research and Industry, San Francisco, CA, USA, 1 February 2014. Published in: Mahadevan-Jansen, Anita and Petrich, Wolfgang eds. Proc. SPIE 8939, Biomedical Vibrational Spectroscopy VI: Advances in Research and Industry. Society of Photo-Optical Instrumentation Engineers, 89390W. 10.1117/12.2044139

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Abstract

Removal of intrinsic brain tumours is a delicate process, where a high degree of specificity is required to remove all of the tumour tissue without damaging healthy brain. The accuracy of this process can be greatly enhanced by intraoperative guidance. Optical biopsies using Raman spectroscopy are a minimally invasive and lower cost alternative to current guidance methods. A miniature Raman probe for performing optical biopsies of human brain tissue is presented. The probe allows sampling inside a conventional stereotactic brain biopsy system: a needle of length 200mm and inner diameter of 1.8mm. The probe achieves a very low fluorescent background whilst maintaining good collection of Raman signal by employing a miniature stand-off Raman design. To illustrate this, the probe is compared with a Raman probe that uses a pair of optical fibres for collection. The miniature stand-off Raman probe is shown to collect a comparable number of Raman scattered photons, but the fluorescence caused by silica fibres in a Raman needle probe is reduced by a factor of two for Raman shifts under 500 cm-1, and by 30% at 600-700 cm-1. In addition, this design contains only medically approved materials at the distal end. The probe’s suitability for use on tissue is demonstrated by discriminating between different types of porcine brain tissue. © (2014) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.

Item Type: Conference or Workshop Item (Paper)
Date Type: Publication
Status: Published
Schools: Biosciences
Medicine
Subjects: R Medicine > R Medicine (General)
Publisher: Society of Photo-Optical Instrumentation Engineers
ISSN: 0277-786X
Last Modified: 04 Jun 2017 08:05
URI: http://orca-mwe.cf.ac.uk/id/eprint/72613

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