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Hepatocyte growth factor induces tyrosine phosphorylation of focal adhesion kinase (FAK) and paxillin and enhances cell-matrix interactions

Jiang, Wen Guo, Hiscox, S., Nakamura, T., Hallett, Maurice Bartlett, Puntis, Malcolm and Mansel, Robert Edward 1996. Hepatocyte growth factor induces tyrosine phosphorylation of focal adhesion kinase (FAK) and paxillin and enhances cell-matrix interactions. Oncology Reports 3 (5) , pp. 819-823. 10.3892/or.3.5.819

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Abstract

This study examined the effects of hepatocyte growth factor/scatter factor (HGF/SF) on the adhesion of HT115 (human colon) and MDA MB 231 (human breast) tumour cells to an extracellular matrix, Matrigel, together with the tyrosine phosphorylation of focal adhesion kinase (FAK) and paxillin. Treatment of cells with HGF increased cell adhesion to matrix. Following adhesion to Matrigel, FAK and paxillin were quickly phosphorylated and located to the focal adhesion area. HGF/SF increased both tyrosine phosphorylation of FAK and paxillin and also increased formation of focal adhesion. HGF also induced an increased spreading on matrix. It is concluded therefore that HGF/SF stimulated FAK and paxillin phosphorylation resulting in an increased tumour-matrix adhesion.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
R Medicine > RZ Other systems of medicine
Additional Information: Full Text Sources Ingenta plc Spandidos Publications - PDF Other Literature Sources COS Scholar Universe Access more work from the authors - ResearchGate Miscellaneous NCI CPTC Antibody Characterization Program
Publisher: Spandidos Publications
ISSN: 1021-335X
Last Modified: 22 Dec 2017 19:52
URI: http://orca-mwe.cf.ac.uk/id/eprint/72597

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