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Consensus Paper: Neuroimmune mechanisms of cerebellar ataxias

Mitoma, Hiroshi, Adhikari, Keya, Aeschlimann, Daniel, Chattopadhyay, Partha, Hadjivassiliou, Marios, Hampe, Christiane S, Honnorat, Jerome, Joubert, Bastien, Kakei, Shinj, Lee, Jongho, Manto, Mario, Matsunaga, Akiko, Mizusawa, Hidehiro, Nanri, Kazunori, Shanmugarajah, Priya, Yoneda, Makoto and Yuki, Nobuhiro 2016. Consensus Paper: Neuroimmune mechanisms of cerebellar ataxias. Cerebellum 15 (2) , pp. 213-232. 10.1007/s12311-015-0664-x

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In the last few years, a lot of publications suggested that disabling cerebellar ataxias may develop through immune-mediated mechanisms. In this consensus paper, we discuss the clinical features of the main described immune-mediated cerebellar ataxias and address their presumed pathogenesis. Immune-mediated cerebellar ataxias include cerebellar ataxia associated with anti-GAD antibodies, the cerebellar type of Hashimoto’s encephalopathy, primary autoimmune cerebellar ataxia, gluten ataxia, Miller Fisher syndrome, ataxia associated with systemic lupus erythematosus, and paraneoplastic cerebellar degeneration. Humoral mechanisms, cell-mediated immunity, inflammation, and vascular injuries contribute to the cerebellar deficits in immune-mediated cerebellar ataxias.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Dentistry
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Additional Information: Available under Open Access
Publisher: Springer
ISSN: 1473-4222
Funders: Bardhan Research and Education Trust of Rotherham, Ryder Briggs Trust
Last Modified: 08 Jul 2019 09:59

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