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Influence of endothelium on drug-induced relaxation of the rabbit aorta

White, David G., Lewis, Malcolm J., Griffith, Tudor M., Edwards, David Hughes and Henderson, Andrew H. 1986. Influence of endothelium on drug-induced relaxation of the rabbit aorta. European Journal of Pharmacology 121 (1) , pp. 19-23. 10.1016/0014-2999(86)90387-0

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Abstract

The influence of endothelium on relaxation induced by glyceryl trinitrate (GTN) and isoprenaline (I) has been studied in isolated rabbit aortic ring preparations, in the resting state and after constriction with 5-hydroxytryptamine (5HT). In resting preparations relaxant responses to GTN and I were smaller in the presence of endothelium. In preparations constricted with 5HT relaxant responses to GTN and I were conversely greater in the presence of endothelium. These paradoxical findings are discussed in relation to basal release of endothelium derived relaxant factor.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Uncontrolled Keywords: Endothelium; Rabbit aorta; Relaxation; Glyceryl trinitrate; Isoprenaline
Publisher: Elsevier
ISSN: 0014-2999
Last Modified: 04 Jun 2017 07:59
URI: http://orca-mwe.cf.ac.uk/id/eprint/71220

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