Determinants of regulated proteolysis in signal transduction

Hasenbein, Sonja, Merdanovic, Melisa and Ehrmann, Michael 2007. Determinants of regulated proteolysis in signal transduction. Genes & Development 21 (1) , pp. 6-10. 10.1101/gad.1507807

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Abstract

Each cell produces thousands of gene products that differ in cellular localization, chemical properties, interactions with other cellular factors, abundance, and half lives. Controlling these events presents an enormous organizational challenge. In recent years, biological quality-control systems were identified addressing this problem. The importance of these systems is underlined by the facts that several quality-control factors are essential for viability and are directly implicated in many severe diseases, such as cancer, cystic fibrosis, amyloid, and autoimmune diseases.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Subjects:	Q Science > QH Natural history > QH426 Genetics
Publisher:	Cold Spring Harbor Laboratory Press
ISSN:	0890-9369
Last Modified:	04 Jun 2017 07:58
URI:	http://orca-mwe.cf.ac.uk/id/eprint/70995

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