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Cryptic ecology among host generalist Campylobacter jejuniin domestic animals

Sheppard, Samuel K., Cheng, Lu, Méric, Guillaume, de Haan, Caroline P. A., Llarena, Ann-Katrin, Marttinen, Pekka, Vidal, Ana, Ridley, Anne, Clifton-Hadley, Felicity, Connor, Thomas Richard, Strachan, Norval J. C., Forbes, Ken, Colles, Frances M., Jolley, Keith A., Bentley, Stephen D., Maiden, Martin C. J., Hänninen, Marja-Liisa, Parkhill, Julian, Hanage, William P. and Corander, Jukka 2014. Cryptic ecology among host generalist Campylobacter jejuniin domestic animals. Molecular Ecology 23 (10) , pp. 2442-2451. 10.1111/mec.12742

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Abstract

Homologous recombination between bacterial strains is theoretically capable of preventing the separation of daughter clusters, and producing cohesive clouds of genotypes in sequence space. However, numerous barriers to recombination are known. Barriers may be essential such as adaptive incompatibility, or ecological, which is associated with the opportunities for recombination in the natural habitat. Campylobacter jejuni is a gut colonizer of numerous animal species and a major human enteric pathogen. We demonstrate that the two major generalist lineages of C. jejuni do not show evidence of recombination with each other in nature, despite having a high degree of host niche overlap and recombining extensively with specialist lineages. However, transformation experiments show that the generalist lineages readily recombine with one another in vitro. This suggests ecological rather than essential barriers to recombination, caused by a cryptic niche structure within the hosts.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Systems Immunity Research Institute (SIURI)
Publisher: Blackwell Publishing
ISSN: 0962-1083
Date of First Compliant Deposit: 21 February 2019
Last Modified: 14 Mar 2019 15:42
URI: http://orca-mwe.cf.ac.uk/id/eprint/70973

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