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Novel astrocyte targets: New avenues for the therapeutic treatment of epilepsy

Crunelli, Vincenzo, Carmignoto, Giorgio and Steinhauser, Christian 2015. Novel astrocyte targets: New avenues for the therapeutic treatment of epilepsy. The Neuroscientist 21 (1) , pp. 62-83. 10.1177/1073858414523320

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Abstract

During the last 20 years, it has been well established that a finely tuned, continuous crosstalk between neurons and astrocytes not only critically modulates physiological brain functions but also underlies many neurological diseases. In particular, this novel way of interpreting brain activity is markedly influencing our current knowledge of epilepsy, prompting a re-evaluation of old findings and guiding novel experimentation. Here, we review recent studies that have unraveled novel and unique contributions of astrocytes to the generation and spread of convulsive and nonconvulsive seizures and epileptiform activity. The emerging scenario advocates an overall framework in which a dynamic and reciprocal interplay among astrocytic and neuronal ensembles is fundamental for a fuller understanding of epilepsy. In turn, this offers novel astrocytic targets for the development of those really novel chemical entities for the control of convulsive and nonconvulsive seizures that have been acknowledged as a key priority in the management of epilepsy.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Medicine
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
R Medicine > RM Therapeutics. Pharmacology
Uncontrolled Keywords: glutamate, GABA, connexin, potassium, temporal lobe epilepsy, absence epilepsy
Publisher: SAGE Publications
ISSN: 1073-8584
Funders: Wellcome Trust
Date of First Compliant Deposit: 30 March 2016
Last Modified: 08 Aug 2017 09:48
URI: http://orca-mwe.cf.ac.uk/id/eprint/70648

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