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Effects of beclamide on isolation-induced aggression and locomotor activity in mice

Darmani, N. A., Sewell, Robert David Edmund and Nicholls, P. J. 1988. Effects of beclamide on isolation-induced aggression and locomotor activity in mice. Journal of Pharmacy and Pharmacology 40 (12) , pp. 891-893. 10.1111/j.2042-7158.1988.tb06297.x

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Abstract

The anti-aggressive effects of orally administered beclamide (N-Benzyl-β-chloropropionamide) have been studied in male albino mice which were individually isolated for a 28-day period. Beclamide (50–250 mg kg−1 p.o.) caused an overall dose-dependent increase in the attack onset latency, a reduction in the percentage of animals attacking and the mean number of attacks/animal for this model of aggression. In addition, the highest dose of beclamide (250 mg kg−1 p.o.) did not significantly modify locomotor activity in mice. It was concluded that beclamide induced anti-aggressive effects at non-sedative doses. This anti-aggressive action was thought be at least partially mediated, through a beclamide-induced release of 5-HT from presynaptic sites.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Pharmacy
Subjects: R Medicine > RS Pharmacy and materia medica
Publisher: Royal Pharmaceutical Society
ISSN: 2042-7158
Last Modified: 04 Jun 2017 07:57
URI: http://orca-mwe.cf.ac.uk/id/eprint/70465

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