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Dopamine-mediated behaviour following chronic treatment with B-HT 920

Darmani, N. A., Sewell, Robert David Edmunds and Nicholls, P. J. 1988. Dopamine-mediated behaviour following chronic treatment with B-HT 920. Journal of Pharmacy and Pharmacology 40 (7) , pp. 523-524.

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Following subchronic (5-day) dosing with B-HT 920 (2-amino-6-allyl-5,6,7,8-tetrahydro-4H-thiazolo(4,5-d)azepine (1 mg kg-1 day-1 i.p.) in rats there was a significant increase in both apomorphine-induced motor activity and stereotypy. On continued B-HT 920 treatment, however, the enhancement of apomorphine motor activity faded into insignificance but the increase in stereotypy persisted beyond 15 days. The results are discussed in terms of dopamine autoreceptor tolerance, postsynaptic D2 supersensitivity and possible differential effects in different brain loci on the above two receptor sub-classes.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Pharmacy
Subjects: R Medicine > RS Pharmacy and materia medica
Publisher: Royal Pharmaceutical Society
ISSN: 2042-7158
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Last Modified: 04 Jun 2017 07:57

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