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Transmission of donor melanoma to multiple organ transplant recipients

Morris-Stiff, G., Steel, A., Savage, P., Devlin, J., Griffiths, David, Portman, B., Mason, Malcolm David and Jurewicz, W. A. 2004. Transmission of donor melanoma to multiple organ transplant recipients. American Journal of Transplantation 4 (3) , pp. 444-446. 10.1111/j.1600-6143.2004.00335.x

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Abstract

Malignant melanoma represents the most common tumour responsible for donor-derived post transplantation malignancies. We report the varied presentation and outcome of three graft recipients (two kidney and hepatic) who developed metastatic melanoma following cadaveric organ transplantation from a single multiorgan donor. Two of the recipients presented with symptomatic metastatic lesions and the third patient, despite being carefully monitored, developed evidence of metastatic cutaneous melanoma. Two of the patients died as a direct result of their melanomas. The recipients of corneal and cardiac grafts remain disease-free. We conclude that despite careful screening, donor-derived tumours remain a not uncommon clinical entity. The identification of a lesion in one recipient should prompt immediate examination and investigation of the remaining recipients of multiorgan donations.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
R Medicine > RZ Other systems of medicine
Publisher: Wiley-Blackwell
ISSN: 1600-6135
Last Modified: 21 Dec 2017 20:34
URI: http://orca-mwe.cf.ac.uk/id/eprint/70241

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