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Crystallographic evidence for isomeric chromophores in 3-fluorotyrosyl-green fluorescent protein

Bae, Jae Hyun, Paramita Pal, Prajna, Moroder, Luis, Huber, Robert and Budisa, Nediljko 2004. Crystallographic evidence for isomeric chromophores in 3-fluorotyrosyl-green fluorescent protein. Chembiochem 5 (5) , pp. 720-722. 10.1002/cbic.200300818

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Abstract

Flipping fluorine chromophores: The unique fluorescence property of the chromophore from green fluorescent protein (GFP) of the jellyfish Aequorea victoria results from the rigid framework of its interactions with the surrounding protein matrix. The three-dimensional structure of 3-fluorotyrosine-containing “enhanced” GFP shows two conformational states of fluorine as an integral part of the chromophore in the crystalline state (see scheme). In this way, chromophore fluorination might be used as a tool to study its flipping and dynamics directly. This will certainly lead to enrichment or even a re-evaluation of the current concepts in this field.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Publisher: Wiley
ISSN: 1439-4227
Last Modified: 24 Jun 2017 11:00
URI: http://orca-mwe.cf.ac.uk/id/eprint/70166

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