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Molecular machines for protein degradation

Groll, Michael, Bochtler, Matthias, Brandstetter, Hans, Clausen, Tim and Huber, Robert 2005. Molecular machines for protein degradation. ChemBioChem 6 (2) , pp. 222-256. 10.1002/cbic.200400313

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One of the most precisely regulated processes in living cells is intracellular protein degradation. The main component of the degradation machinery is the 20S proteasome present in both eukaryotes and prokaryotes. In addition, there exist other proteasome-related protein-degradation machineries, like HslVU in eubacteria. Peptides generated by proteasomes and related systems can be used by the cell, for example, for antigen presentation. However, most of the peptides must be degraded to single amino acids, which are further used in cell metabolism and for the synthesis of new proteins. Tricorn protease and its interacting factors are working downstream of the proteasome and process the peptides into amino acids. Here, we summarise the current state of knowledge about protein-degradation systems, focusing in particular on the proteasome, HslVU, Tricorn protease and its interacting factors and DegP. The structural information about these protein complexes opens new possibilities for identifying, characterising and elucidating the mode of action of natural and synthetic inhibitors, which affects their function. Some of these compounds may find therapeutic applications in contemporary medicine.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Subjects: Q Science > QR Microbiology
Uncontrolled Keywords: molecular machines; proteasomes; protein degradation; protein structures; structure–activity relationships
Publisher: Wiley-Blackwell
ISSN: 1439-4227
Last Modified: 24 Jun 2017 11:00

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