Toward a molecular understanding of the structure-function of ryanodine receptor Ca2+ release channels

George, Christopher, Yin, Chang Cheng and Lai, Francis Anthony ORCID: https://orcid.org/0000-0003-2852-8547 2005. Toward a molecular understanding of the structure-function of ryanodine receptor Ca2+ release channels. Cell Biochemistry and Biophysics 42 (2) , pp. 197-222. 10.1385/CBB:42:2:197

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Abstract

Identification of the genetic basis of human diseases linked to dysfunctional free calcium (Ca2+) signaling has triggered an explosion of interest in the functional characterization of the molecular components regulating intracellular Ca2+ homeostasis. There is a growing appreciation of the central role of intracellular ryanodine-sensitive Ca2+ release channel (RyR) regulation in skeletal and cardiac muscle pathologies, including malignant hyperthermia, heart failure, and sudden cardiac death. The use of cloned RyR isoforms and recombinant expression techniques has greatly facilitated the elucidation of the molecular basis of RyR Ca2+ release functionality. This review will focus on the recombinant techniques used in the functional characterization of recombinant RyR isoforms and the insights that these approaches have yielded in unraveling the mechanistic basis of RyR channel functionality.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General)
Uncontrolled Keywords:	Ca2+ release channel, regulation, recombinant expression. function.
Publisher:	Springer
ISSN:	1085-9195
Last Modified:	27 Oct 2022 10:09
URI:	https://orca.cardiff.ac.uk/id/eprint/69115

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