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Comparative evaluation of gastroulcerogenic potential of nitrogen isoforms of salicyl alcohol and aspirin in rats: biochemical and histological study

Ali, Gowhar, Subhan, Fazal, Islam, Nazar Ul, Ullah, Nasir, Shahid, Muhammad, Ullah, Sami, Ullah, Ihsan, Shah, Rehmat, Khan, Ikhtiar, Sewell, Robert David Edmund and Abbas, Ghulam 2013. Comparative evaluation of gastroulcerogenic potential of nitrogen isoforms of salicyl alcohol and aspirin in rats: biochemical and histological study. Archives of Pharmacal Research 37 (7) , pp. 916-926. 10.1007/s12272-013-0245-9

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Abstract

The aim of the current study was to explore in vivo any relative gastroulcerogenic prospective propensity of newly synthesized nitrogen containing derivatives of salicyl alcohol; compound (I) [1-(2-hydroxybenzyl)piperidinium chloride], compound (II) [4-carbamoyl-1-(2-hydroxybenzyl)piperidinium chloride] and aspirin in albino rats. The experimental groups received the following oral treatments daily for 6 days: group I saline control; group II, standard (aspirin) treatment group [150 mg/kg of body weight]; group III, test (compound I) treatment group [100, 150 mg/kg]; group IV, test (compound II) treatment group [100, 150 mg/kg]. The results showed that in the case of the aspirin treated group and compound (I) [150 mg/kg], there was a significant increase in gastric volume, free acidity, total acidity, ulcer score and a decrease in gastric pH. Furthermore, histopathological examination of gastric mucosa of these treated groups revealed detectable morphological changes. Utilizing the same protocol, synthetic compound (I) [100 mg/kg] and (II) [100, 150 mg/kg] exhibited no statistically significant ulcerogenic or cytotoxic properties. A cyclooxygenase (COX) selectivity test indicated the preferential inhibition of COX-I and COX-II enzymes by compounds (I) and (II). This study therefore indicates that these synthetic compounds may possess reduced ulcerogenic potential and could be a functional substitute to aspirin.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Pharmacy
Publisher: Pharmaceutical Society of Korea
ISSN: 0253-6269
Last Modified: 04 Jun 2017 07:51
URI: http://orca-mwe.cf.ac.uk/id/eprint/68897

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