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Convenient synthesis of diaryliodonium salts for the production of [18F]F-DOPA

Edwards, Richard, Westwell, Andrew D., Daniels, Stephen and Wirth, Thomas 2015. Convenient synthesis of diaryliodonium salts for the production of [18F]F-DOPA. European Journal of Organic Chemistry 2015 (3) , pp. 625-630. 10.1002/ejoc.201403378

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Abstract

[18F]F-DOPA is an important radiotracer that is used in the diagnosis of Parkinson's disease and neuroendocrine tumours. We describe a simple synthesis for a number of diaryliodonium salt precursors that are suitable for the production of [18F]F-DOPA through reaction with no carrier added (n.c.a.) nucleophilic [18F]fluoride. The simple procedure gives bench-stable, complex iodonium precursors in good yields without the need for laborious anhydrous conditions. Further alteration to the precursor counterion can be readily achieved for a range of halides and pseudo halides by a simple modification of the workup. Preliminary “hot” and “cold” fluorination results show the suitability of the compounds for the production of [18F]F-DOPA.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Chemistry
Pharmacy
Subjects: Q Science > QD Chemistry
Uncontrolled Keywords: Analytical methods / Isotopic labeling / Imaging agents / Fluorination / PET / Radiochemistry
Publisher: Wiley
ISSN: 1434-193X
Date of First Compliant Deposit: 31 March 2017
Date of Acceptance: 9 December 2014
Last Modified: 21 Oct 2019 15:06
URI: http://orca-mwe.cf.ac.uk/id/eprint/68275

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