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Efficacy and pharmacokinetics of a new controlled-release morphine sulfate 200-mg tablet

Hanks, G. W., Hanna, M., Finlay, Ilora Gillian, Radstone, D. J. and Keeble, T. 1995. Efficacy and pharmacokinetics of a new controlled-release morphine sulfate 200-mg tablet. Journal of Pain and Symptom Management 10 (1) , pp. 6-12. 10.1016/0885-3924(94)00067-u

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Abstract

Nineteen of 25 patients (14 female) with advanced malignant disease completed a randomized controlled trial of a new high-dose (200 mg) tablet formulation of controlled-release morphine. Compared with the currently available 100-mg tablets there were no differences in pain severity or adverse effects with the new formulation. In four patients, full 12-hr plasma morphine concentration profiles at steady state were obtained and showed no significant differences between the same dose provided as 100-mg and 200-mg tablets in Cmax, tmax, or other pharmacokinetic indices.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
R Medicine > RZ Other systems of medicine
Publisher: Elsevier
ISSN: 0885-3924
Last Modified: 04 Jun 2017 07:47
URI: http://orca-mwe.cf.ac.uk/id/eprint/68003

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