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Emotional face recognition deficits and medication effects in pre-manifest through stage-II Huntington's disease

Labuschagne, Izelle, Jones, Rebecca, Callaghan, Jenny, Whitehead, Daisy, Dumas, Eve M., Say, Miranda J., Hart, Ellen P., Justo, Damian, Coleman, Allison, Dar Santos, Rachelle C., Frost, Chris, Craufurd, David, Tabrizi, Sarah J. and Stout, Julie C. 2013. Emotional face recognition deficits and medication effects in pre-manifest through stage-II Huntington's disease. Psychiatry Research 207 (1-2) , pp. 118-126. 10.1016/j.psychres.2012.09.022

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Abstract

Facial emotion recognition impairments have been reported in Huntington's disease (HD). However, the nature of the impairments across the spectrum of HD remains unclear. We report on emotion recognition data from 344 participants comprising premanifest HD (PreHD) and early HD patients, and controls. In a test of recognition of facial emotions, we examined responses to six basic emotional expressions and neutral expressions. In addition, and within the early HD sample, we tested for differences on emotion recognition performance between those ‘on’ vs. ‘off’ neuroleptic or selective serotonin reuptake inhibitor (SSRI) medications. The PreHD groups showed significant (p<0.05) impaired recognition, compared to controls, on fearful, angry and surprised faces; whereas the early HD groups were significantly impaired across all emotions including neutral expressions. In early HD, neuroleptic use was associated with worse facial emotion recognition, whereas SSRI use was associated with better facial emotion recognition. The findings suggest that emotion recognition impairments exist across the HD spectrum, but are relatively more widespread in manifest HD than in the premanifest period. Commonly prescribed medications to treat HD-related symptoms also appear to affect emotion recognition. These findings have important implications for interpersonal communication and medication usage in HD.

Item Type: Article
Status: Published
Schools: Biosciences
Publisher: Elsevier
ISSN: 0165-1781
Last Modified: 10 Jun 2020 01:27
URI: http://orca-mwe.cf.ac.uk/id/eprint/67604

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