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Enantiomeric separation of aminoglutethimide, acetyl aminoglutethimide, and dansyl aminoglutethimide by tlc with beta-cyclodextrin and derivatives as mobile phase additives

Aboul-Enein, H. Y., El-Awady, M. I. and Heard, Charles Martin 2000. Enantiomeric separation of aminoglutethimide, acetyl aminoglutethimide, and dansyl aminoglutethimide by tlc with beta-cyclodextrin and derivatives as mobile phase additives. Journal of Liquid Chromatography and Related Technologies 23 (17) , pp. 2715-2726. 10.1081/JLC-100101829

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Abstract

Racemic aminoglutethimide and acetylaminoglutethimide were resolved on a fluorescent Silica gel 60A TLC plate using 30% hydroxy trimethylpropylammonium-β-cyclodextrin with methanol (50:50v/v) as the mobile phase. Also, the resolution of the enantiomers of aminoglutethimide as dansyl derivatives were investigated on reversed phase TLC using a mobile phase consisting of a β-cyclodextrin solution (0.05 M saturated with urea), or 15% (carboxymethyl-β-cyclodextrin) solution with methanol (65:35v/v). Enantiomeric resolution was found to be highly dependent on mobile phase composition. The effect of the type and amount of organic modifier as well as the concentration of β-CD derivative, and the pH of the mobile phase on resolution were studied. Three types of maltodextrins failed to show resolution for any of the racemic compounds studied.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Pharmacy
Subjects: R Medicine > RS Pharmacy and materia medica
Publisher: Taylor and Francis
ISSN: 1082-6076
Last Modified: 04 Jun 2017 07:44
URI: http://orca-mwe.cf.ac.uk/id/eprint/67503

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