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Host genetic background determines whether IL-18 deficiency results in increased susceptibility or resistance to murine Leishmania major infection

Wei, Xiao-Qing, Niedbala, Wanda, Xu, Damo, Luo, Zhao-Xia, Pollock, Kevin G. J. and Brewer, James M. 2004. Host genetic background determines whether IL-18 deficiency results in increased susceptibility or resistance to murine Leishmania major infection. Immunology Letters 94 (1-2) , pp. 35-37. 10.1016/j.imlet.2004.04.001

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Abstract

Interleukin-18 (IL-18) plays an important role in innate and acquired immunity. IL-18 gene deficient (IL-18-/-) mice of the 129×CD1 strain were reported to be more susceptible to Leishmania major infection than the wild-type mice. In contrast IL-18-/- mice of the C57BL/6 background were found to be as resistant as the wild-type (WT) mice. To resolve this discrepancy, IL-18 gene deficiency was introduced by backcrossing on to the highly susceptible BALB/c, or the moderately resistant DBA/1 backgrounds. Here we have demonstrated that BALB/c IL-18-/- mice were more resistant to L. major infection than WT BALB/c mice, whereas DBA/1 IL-18-/- mice were markedly more susceptible than their WT littermates. BALB/c IL-18-/- mice produced less IFNγ and IL-4, whereas DBA/1 IL-18ko mice produced more IFNγ and IL-4 than their respective WT controls. These result clearly demonstrate that the role of IL-18 in resistance or susceptibility to L. major is determined by host genetic background.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Dentistry
Subjects: Q Science > QR Microbiology > QR180 Immunology
Uncontrolled Keywords: Th1/Th2 ; Infectious immunity-parasite ; Cytokines ; Knockout
Publisher: Elsevier
ISSN: 0165-2478
Last Modified: 04 Jun 2017 01:35
URI: http://orca-mwe.cf.ac.uk/id/eprint/670

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