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Latrophilin signaling links anterior-posterior tissue polarity and oriented cell divisions in the C. elegans embryo

Langenhan, Tobias, Prömel, Simone, Mestek, Lamia, Esmaeili, Behrooz, Waller-Evans, Helen, Hennig, Christian, Kohara, Yuji, Avery, Leon, Vakonakis, Ioannis, Schnabel, Ralf and Russ, Andreas P. 2009. Latrophilin signaling links anterior-posterior tissue polarity and oriented cell divisions in the C. elegans embryo. Developmental Cell 17 (4) , pp. 494-504. 10.1016/j.devcel.2009.08.008

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Abstract

Understanding the mechanisms that coordinate the orientation of cell division planes during embryogenesis and morphogenesis is a fundamental problem in developmental biology. Here we show that the orphan receptor lat-1, a homolog of vertebrate latrophilins, plays an essential role in the establishment of tissue polarity in the C. elegans embryo. We provide evidence that lat-1 is required for the alignment of cell division planes to the anterior-posterior axis and acts in parallel to known polarity and morphogenesis signals. lat-1 is a member of the Adhesion-GPCR protein family and is structurally related to flamingo/CELSR, an essential component of the planar cell polarity pathway. We dissect the molecular requirements of lat-1 signaling and implicate lat-1 in an anterior-posterior tissue polarity pathway in the premorphogenesis stage of C. elegans development.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Publisher: Elsevier
ISSN: 1534-5807
Last Modified: 04 Jun 2017 07:41
URI: http://orca-mwe.cf.ac.uk/id/eprint/66957

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