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Effects of fulvestrant 250 mg in premenopausal women with oestrogen receptor-positive primary breast cancer

Robertson, J. F. R., Semiglazov, V., Nemsadze, G., Dzagnidze, G., Janjalia, M., Nicholson, Robert Ian, Gee, Julia Margaret Wendy and Armstrong, J. 2007. Effects of fulvestrant 250 mg in premenopausal women with oestrogen receptor-positive primary breast cancer. European Journal of Cancer 43 (1) , pp. 64-70. 10.1016/j.ejca.2006.08.019

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Abstract

Fulvestrant (Faslodex™) reduces markers of hormone sensitivity and proliferation in postmenopausal women. This Phase II double-blind, randomised, multicentre study compared the effects of a single 250mg intramuscular dose of fulvestrant and placebo 14–21 days prior to surgery of curative intent on the oestrogen receptor (ER), progesterone receptor and Ki67 levels in 66 premenopausal women with ER-positive primary breast cancer. There were no statistically significant differences between fulvestrant and placebo with respect to any of the three markers analysed. The most common adverse events in both groups were nausea, headache and pyrexia. Fulvestrant 250mg had no effects on markers of hormone-sensitivity and proliferation in premenopausal women with primary breast cancer when measured at 14–21 days after injection. These findings suggest that a higher fulvestrant dose may be required in this patient population. Further clinical trials are necessary to evaluate the efficacy of fulvestrant in premenopausal women.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Pharmacy
Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
R Medicine > RM Therapeutics. Pharmacology
Uncontrolled Keywords: Fulvestrant, Premenopausal, Breast cancer, Oestrogen receptor, Progesterone receptor, Ki67
Publisher: Elsevier
ISSN: 0959-8049
Last Modified: 04 Jun 2017 01:58
URI: http://orca-mwe.cf.ac.uk/id/eprint/6692

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