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Intrastriatal dopamine-rich grafts induce a hyperexpression of Fos protein when challenged with amphetamine

Abrous, D. N., Torres, Eduardo MIguel, Annett, L. E., Reading, P. J. and Dunnett, Stephen Bruce 1992. Intrastriatal dopamine-rich grafts induce a hyperexpression of Fos protein when challenged with amphetamine. Experimental Brain Research 91 (2) , pp. 181-190. 10.1007/BF00231653

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The aim of the present experiment was to characterize the effect of intrastriatal grafts of embryonic dopaminergic neurones on the expression of Fos protein in the striatum when challenged with amphetamine. Unilateral 6-hydroxydopamine lesions of the nigrostriatal pathway were made in adult rats and grafting was performed 3 weeks later. The numbers of Fos-positive nuclei in the ipsi- and contralateral striata were counted on coronal sections following immunohistochemical staining 5 months after grafting. Administration of d-amphetamine induced an increase in the density of Fospositive nuclei in the intact striatum. This stimulatory effect of amphetamine on c-fos expression was blocked by 6-hydroxydopamine hydrobromide lesions and was restored in the striata bearing transplants. However, an overshoot was observed as the density of Fos-positive cells within the grafted striatum was larger than that observed within the intact striatum. This hyperexpression of Fos-positive nuclei was correlated with the exaggerated compensation of amphetamine-induced rotation in the same animals.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Publisher: Springer
ISSN: 0014-4819
Last Modified: 04 Jun 2017 07:35

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