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Aromatase inhibitors in breast cancer

Hiscox, Stephen Edward, Davies, Eleri-Lloyd and Barrett-Lee, Peter 2009. Aromatase inhibitors in breast cancer. Maturitas 63 (4) , pp. 275-279. 10.1016/j.maturitas.2009.05.008

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Abstract

Estrogens play important roles in breast cancer development and progression. In postmenopausal women, traditional endocrine therapies such as tamoxifen have sought to inhibit estrogen action by targeting the estrogen receptor itself. However, newer treatments are evolving that target estrogen production in postmenopausal tissues through inhibition of the aromatase enzyme. Clinical data demonstrate that these aromatase inhibitors are superior to tamoxifen as adjuvant therapy for breast cancer and have now replaced tamoxifen as first line therapy in a number of treatment regimens for postmenopausal breast cancer patients.

Item Type: Article
Status: Published
Schools: Pharmacy
Medicine
Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Uncontrolled Keywords: Aromatase inhibitors; SERM; Tamoxifen; Aromatase; Estrogen
Publisher: Elsevier
ISSN: 0378-5122
Last Modified: 18 Oct 2017 13:11
URI: http://orca-mwe.cf.ac.uk/id/eprint/6567

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