Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

How do mammillary body inputs contribute to anterior thalamic function?

Dillingham, Christopher Mark, Frizzati, Aura, Nelson, Andrew John Dudley and Vann, Seralynne Denise 2015. How do mammillary body inputs contribute to anterior thalamic function? Neuroscience & Biobehavioral Reviews 54 , pp. 108-119. 10.1016/j.neubiorev.2014.07.025

[img] PDF - Published Version
Available under License Creative Commons Attribution.

Download (2MB)

Abstract

It has long been assumed that the main function of the mammillary bodies is to provide a relay for indirect hippocampal inputs to the anterior thalamic nuclei. Such models afford the mammillary bodies no independent role in memory and overlook the importance of their other, non-hippocampal, inputs. This review focuses on recent advances that herald a new understanding of the importance of the mammillary bodies, and their inputs from the limbic midbrain, for anterior thalamic function. It has become apparent that the mammillary bodies’ contribution to memory is not dependent on afferents from the subicular complex. Rather, the ventral tegmental nucleus of Gudden is a vital source of inputs that support memory processes within the medial mammillary bodies. In parallel, the lateral mammillary bodies, via their connections with the dorsal tegmental nucleus of Gudden, are critical for generating head-direction signals. These two parallel, but distinct, information streams converge on the anterior thalamic nuclei and support different aspects of spatial memory.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Psychology
Subjects: B Philosophy. Psychology. Religion > BF Psychology
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords: Anterior thalamic nucleus; Diencephalon; Gudden's tegmental nuclei; Learning and memory; Mammillary bodies; Mammillothalamic tract
Publisher: Elsevier
ISSN: 0149-7634
Funders: Wellcome Trust
Date of First Compliant Deposit: 30 March 2016
Last Modified: 21 Aug 2019 02:12
URI: http://orca-mwe.cf.ac.uk/id/eprint/65654

Citation Data

Cited 4 times in Google Scholar. View in Google Scholar

Cited 33 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item

Downloads

Downloads per month over past year

View more statistics