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Cloning and sequencing of a Xenopus homologue of the inducible orphan receptor NGFI-B

Smith, Trudi S., Matharu, Philip J. and Sweeney, Glen E. 1993. Cloning and sequencing of a Xenopus homologue of the inducible orphan receptor NGFI-B. Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1173 (2) , pp. 239-242. 10.1016/0167-4781(93)90189-K

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A cDNA clone encoding the NGFI-B transcription factor, a growth factor inducible member of the steroid/thyroid receptor superfamily, has been isolated from a Xenopus neurula (stage 17 embryo) library. Sequencing of this clone reveals an open reading frame encoding a 577 amino acid protein. Comparisons with its counterparts in rat, mouse and human show that the Xenopus protein has a well conserved DNA binding domain whereas homology in the carboxy terminal region, which includes the putative ligand binding domain, is lower than that typically observed in members of the steroid/thyroid receptor superfamily. This relative lack of homology suggests that, in Xenopus, the as-yet uncharacterised ligand may have subtle distinctions from its mammalian counterparts.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Publisher: Elsevier
ISSN: 0167-4781
Last Modified: 02 May 2019 11:01

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