Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Thyroid hormone receptor expression during metamorphosis of Atlantic halibut (Hippoglossus hippoglossus)

Galay-Burgos, Malyka, Power, Deborah M., Llewellyn, Lynda and Sweeney, Glen E. 2008. Thyroid hormone receptor expression during metamorphosis of Atlantic halibut (Hippoglossus hippoglossus). Molecular and Cellular Endocrinology 281 (1-2) , pp. 56-63. 10.1016/j.mce.2007.10.009

Full text not available from this repository.


Flatfish such as the Atlantic halibut (Hippoglossus hippoglossus) undergo a dramatic metamorphosis that transforms the pelagic, symmetric larva into a benthic, cranially asymmetric juvenile. In common with amphibian metamorphosis, flatfish metamorphosis is under endocrine control with thyroid hormones being particularly important. In this report we confirm that tri-iodothyronine (T3) levels peak at metamorphic climax during halibut metamorphosis. Moreover, we have isolated cDNA clones of TRα and TRβ genes and confirmed the presence in halibut of two TRα isoforms (representing the products of distinct genes) and two TRβ isoforms (generated from a single gene by alternative splicing). Real-time PCR was used to assess expression of these genes during metamorphosis. TRβ shows the most dramatic expression profile, with a peak occurring during metamorphic climax.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Publisher: Elsevier
ISSN: 0303-7207
Last Modified: 02 May 2019 10:58

Citation Data

Cited 36 times in Google Scholar. View in Google Scholar

Cited 38 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item