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Using mouse models to investigate sex-linked genetic effects on brain, behaviour and vulnerability to neuropsychiatric disorders

Davies, William 2013. Using mouse models to investigate sex-linked genetic effects on brain, behaviour and vulnerability to neuropsychiatric disorders. Brain Research Bulletin 92 , pp. 12-20. 10.1016/j.brainresbull.2011.06.018

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Abstract

Many brain and behavioural phenotypes in humans exhibit some degree of sexual dimorphism. Moreover, there are large and replicable differences in the vulnerability of the two sexes to a wide range of common brain disorders. Ultimately, sex differences in healthy individuals, or in pathological states, must arise as a consequence of the differential complement of sex-linked genes in males and females. These genes may act indirectly (for example through influencing gonadal hormone secretion), or directly, to influence brain development and function. In this review, I discuss how genetically tractable mouse models may be employed to inform our knowledge of the molecular basis of sexual differentiation of the mammalian brain, and how such models may therefore represent a useful tool through which to identify risk factors predisposing to sex-biased neuropsychiatric disorders.

Item Type: Article
Date Type: Publication
Status: Published
Schools: MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Medicine
Neuroscience and Mental Health Research Institute (NMHRI)
Psychology
Subjects: B Philosophy. Psychology. Religion > BF Psychology
Q Science > QH Natural history > QH426 Genetics
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords: Attention deficit hyperactivity disorder; Autism; Four core genotypes; Imprinted gene; Klinefelter syndrome; Turner syndrome
Publisher: Elsevier
ISSN: 0361-9230
Date of First Compliant Deposit: 30 March 2016
Last Modified: 27 Jun 2019 15:21
URI: http://orca-mwe.cf.ac.uk/id/eprint/64773

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