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Chloroplast biogenesis is regulated by direct action of the ubiquitin-proteasome system

Ling, Qihau, Huang, Weihua, Baldwin, Amy Joy and Jarvis, Paul 2012. Chloroplast biogenesis is regulated by direct action of the ubiquitin-proteasome system. Science 338 (6107) , pp. 655-659. 10.1126/science.1225053

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Abstract

Development of chloroplasts and other plastids depends on the import of thousands of nucleus-encoded proteins from the cytosol. Import is initiated by TOC (translocon at the outer envelope of chloroplasts) complexes in the plastid outer membrane that incorporate multiple, client-specific receptors. Modulation of import is thought to control the plastid’s proteome, developmental fate, and functions. Using forward genetics, we identified Arabidopsis SP1, which encodes a RING-type ubiquitin E3 ligase of the chloroplast outer membrane. The SP1 protein associated with TOC complexes and mediated ubiquitination of TOC components, promoting their degradation. Mutant sp1 plants performed developmental transitions that involve plastid proteome changes inefficiently, indicating a requirement for reorganization of the TOC machinery. Thus, the ubiquitin-proteasome system acts on plastids to control their development.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Publisher: American Association for the Advancement of Science
ISSN: 0036-8075
Last Modified: 04 Jun 2017 06:45
URI: http://orca-mwe.cf.ac.uk/id/eprint/64409

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