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Synthesis and antioxidant activities of novel chiral ebselen analogues

Elsherbini, Mohamed Sobh, Hamama, Wafaa S., Zoorob, Hanafi H., Bhowmick, Debasish, Mugesh, Govindasamy and Wirth, Thomas 2014. Synthesis and antioxidant activities of novel chiral ebselen analogues. Heteroatom Chemistry 25 (5) , pp. 320-325. 10.1002/hc.21164

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Abstract

Novel chiral analogues of the antioxidant, anti-inflammatory organoselenium drug ebselen were synthesized. The reaction proceeded readily from 2-(chloroseleno)benzoyl chloride with chiral amino compounds. The chiral substituent on the nitrogen atom did not provide a substantial increase in activities and the newly synthesized compounds showed similar activities to ebselen.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Chemistry
Subjects: Q Science > QD Chemistry
Additional Information: Article first published online: 9 MAY 2014
Publisher: Wiley-Blackwell
ISSN: 1042-7163
Date of Acceptance: 23 March 2014
Last Modified: 18 Feb 2019 13:36
URI: http://orca-mwe.cf.ac.uk/id/eprint/63618

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