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Genetic and phenotypic analysis of the genes of the elbow-no-ocelli region of chromosome 2L of Dvosophila melanogaster

Davis, Terence, Ashburner, Michael, Johnson, Glynnis, Gubb, David and Roote, John 1997. Genetic and phenotypic analysis of the genes of the elbow-no-ocelli region of chromosome 2L of Dvosophila melanogaster. Hereditas 126 (1) , pp. 67-75. 10.1111/j.1601-5223.1997.00067.x

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Abstract

The elbow locus is found to be two genes elA and elB, each of which has a distinct phenotype when mutant. Mutations of the elA gene have a strong phenotype where the wing is markedly disrupted. Mutations of elB are weak, mainly affecting the alula and the wing bristles. The two genes are dominant enhancers of each other. Homozygous deletion of the complete elbow region results in lethality. Situated between the elbow genes is the pupal gene and a locus which when deleted causes a crippled leg phenotype. This locus may be a control region for elbow. Immediately adjacent on the proximal side of elA is the no-ocelli locus. The phenotypes of noc alleles vary from extreme, where the ocelli and associated bristles are absent, to weak where these structures are disrupted. The various noc phenotypes are associated with genetically distinct gene regions, mutations of which act as enhancers of each other. Alleles of el and noc show partial failure of complementation, heterozygotes having weak el or weak noc phenotypes. Alleles of both these genes interact with the antimorphic noc allele Sco.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: Q Science > QH Natural history > QH426 Genetics
R Medicine > R Medicine (General)
Publisher: Wiley
ISSN: 0018-0661
Last Modified: 04 Jun 2017 06:40
URI: http://orca-mwe.cf.ac.uk/id/eprint/63571

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