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Microwave-assisted synthesis of N-pyrazole ureas and the p38α inhibitor BIRB 796 for study into accelerated cell ageing

Bagley, Mark C., Davis, Terence, Dix, Matthew C., Widdowson, Caroline S. and Kipling, David Glyn 2006. Microwave-assisted synthesis of N-pyrazole ureas and the p38α inhibitor BIRB 796 for study into accelerated cell ageing. Organic & Biomolecular Chemistry 4 (22) , pp. 4158-4164. 10.1039/b611493h

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Abstract

Microwave irradiation of substituted hydrazines and β-ketoesters gives 5-aminopyrazoles in excellent yield, which can be transformed to the corresponding N-carbonyl derivatives by treatment with an isocyanate or chloroformate. Derivatization of 4-nitronaphth-1-ol using predominantly microwave heating methods and reaction with an N-pyrazole carbamate provides a rapid route to the N-pyrazole urea BIRB 796 in high purity, as a potent and selective inhibitor of p38α mitogen-activated protein kinase for the study of accelerated ageing in Werner syndrome cells.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Chemistry
Medicine
Subjects: R Medicine > R Medicine (General)
Publisher: Royal Society of Chemistry
ISSN: 1477-0520
Last Modified: 04 Jun 2017 06:40
URI: http://orca-mwe.cf.ac.uk/id/eprint/63543

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