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Block in development at the pre-B-II to immature B cell stage in mice without lgk and iga light chain

Zou, Xiangang, Piper, Tony A., Smith, J. A., Allen, Nicholas Denby, Xian, Jian and Bruggemann, Marianne 2003. Block in development at the pre-B-II to immature B cell stage in mice without lgk and iga light chain. The Journal of Immunology 170 (3) , pp. 1354-1361.

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Abstract

Silencing individual C (constant region) lambda genes in a kappa(-/-) background reduces mature B cell levels, and L chain-deficient (lambda(-/-)kappa(-/-)) mice attain a complete block in B cell development at the stage when L chain rearrangement, resulting in surface IgM expression, should be completed. L chain deficiency prevents B cell receptor association, and L chain function cannot be substituted (e.g., by surrogate L chain). Nevertheless, precursor cell levels, controlled by developmental progression and checkpoint apoptosis, are maintained, and B cell development in the bone marrow is fully retained up to the immature stage. L chain deficiency allows H chain retention in the cytoplasm, but prevents H chain release from the cell, and as a result secondary lymphoid organs are B cell depleted while T cell levels remain normal.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: Q Science > Q Science (General)
Publisher: Wiley Blackwell
ISSN: 0019-2805
Last Modified: 04 Jun 2017 06:40
URI: http://orca-mwe.cf.ac.uk/id/eprint/63495

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