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Physiological and pharmacological agonists of the extracellular Ca2+-sensing receptor

McLarnon, Stuart J. and Riccardi, Daniela 2002. Physiological and pharmacological agonists of the extracellular Ca2+-sensing receptor. European Journal of Pharmacology 447 (2-3) , pp. 271-278. 10.1016/S0014-2999(02)01849-6

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Extracellular Ca2+ concentration [Ca2+]o is vital for a number of processes varying from blood clotting to regulation membrane permeability and excitability. For this reason [Ca2+]o is under strict control of a complex homeostatic system that includes parathyroid glands, kidneys, bones and intestine. The extracellular Ca2+-sensing receptor is an essential component of this system, regulating parathyroid hormone secretion, Ca2+ (and Mg2+) excretion by the kidney, bone remodeling and Ca2+ reabsorption by the gastrointestinal tract. The Ca2+-sensing receptor is also present in organs without an obvious link with mineral ion metabolism. This review will describe the discovery of a novel class of ion-sensing receptor(s), receptor–effector coupling and the roles of the Ca2+-sensing receptor inside and outside the Ca2+o homeostatic system.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Publisher: Elsevier
ISSN: 0014-2999
Last Modified: 04 Jun 2017 06:40

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