Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Tandem-Pore K+ channels mediate inhibition of orexin neurons by glucose

Burdakov, Denis, Jensen, Lise T., Alexopoulos, Haris, Williams, Rhiannan H., Fearon, Ian M., O'Kelly, Ita, Gerasimenko, Oleg Vsevolodovich, Fugger, Lars and Verkhratsky, Alexei 2006. Tandem-Pore K+ channels mediate inhibition of orexin neurons by glucose. Neuron -Cambridge Ma- 50 (5) , pp. 711-722. 10.1016/j.neuron.2006.04.032

Full text not available from this repository.

Abstract

Glucose-inhibited neurons orchestrate behavior and metabolism according to body energy levels, but how glucose inhibits these cells is unknown. We studied glucose inhibition of orexin/hypocretin neurons, which promote wakefulness (their loss causes narcolepsy) and also regulate metabolism and reward. Here we demonstrate that their inhibition by glucose is mediated by ion channels not previously implicated in central or peripheral glucose sensing: tandem-pore K+ (K2P) channels. Importantly, we show that this electrical mechanism is sufficiently sensitive to encode variations in glucose levels reflecting those occurring physiologically between normal meals. Moreover, we provide evidence that glucose acts at an extracellular site on orexin neurons, and this information is transmitted to the channels by an intracellular intermediary that is not ATP, Ca2+, or glucose itself. These results reveal an unexpected energy-sensing pathway in neurons that regulate states of consciousness and energy balance.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Publisher: Elsevier
ISSN: 0896-6273
Last Modified: 04 Jun 2017 06:39
URI: http://orca-mwe.cf.ac.uk/id/eprint/63356

Citation Data

Cited 194 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item