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The endoplasmic reticulum: one continuous or several separate Ca2+ stores?

Petersen, Ole Holger, Tepikin, Alexei and Park, Myoung Kyu 2001. The endoplasmic reticulum: one continuous or several separate Ca2+ stores? Trends in Neurosciences 24 (5) , pp. 271-276. 10.1016/S0166-2236(00)01787-2

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Abstract

The Ca2+ store and sink in the endoplasmic reticulum (ER) is important for Ca2+ signal integration and for conveyance of information in spatial and temporal domains. Textbooks regard the ER as one continuous network, but biochemical and biophysical studies revealed apparently discrete ER Ca2+ stores. Recent direct studies of ER lumenal Ca2+ movements show that this organelle system is one continuous Ca2+ store, which can function as a Ca2+ tunnel. The concept of a fully connected ER network is entirely compatible with evidence indicating that the distribution of Ca2+-release channels in the ER membrane is discontinuous with clustering in certain localities.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Systems Immunity Research Institute (SIURI)
Uncontrolled Keywords: oscillation; cytosol; photobleachin; lumen; spiking; sarcoplasmic; fluorescence
Publisher: Elsevier
ISSN: 0166-2236
Last Modified: 04 Jun 2017 06:38
URI: http://orca-mwe.cf.ac.uk/id/eprint/63164

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