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Free radicals and the pancreatic acinar cells: role in physiology and pathology

Chvanov, M., Petersen, Ole Holger and Tepikin, A. 2005. Free radicals and the pancreatic acinar cells: role in physiology and pathology. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences 360 (1464) , pp. 2273-2284. 10.1098/rstb.2005.1757

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Abstract

Reactive oxygen and nitrogen species (ROS and RNS) play an important role in signal transduction and cell injury processes. Nitric oxide synthase (NOS)—the key enzyme producing nitric oxide (NO)—is found in neuronal structures, vascular endothelium and, possibly, in acinar and ductal epithelial cells in the pancreas. NO is known to regulate cell homeostasis, and its effects on the acinar cells are reviewed here. ROS are implicated in the early events within the acinar cells, leading to the development of acute pancreatitis. The available data on ROS/RNS involvement in the apoptotic and necrotic death of pancreatic acinar cells will be discussed.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Systems Immunity Research Institute (SIURI)
Uncontrolled Keywords: nitric oxide; reactive oxygen species; reactive nitrogen species; pancreatic acinar cells; pancreatitis
Publisher: Royal Society
ISSN: 0962-8436
Last Modified: 04 Jun 2017 06:38
URI: http://orca-mwe.cf.ac.uk/id/eprint/63125

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