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Characterisation of CadR from Pseudomonas aeruginosa: a Cd(II)-responsive MerR homologue

Brocklehurst, K. R, Megit, S. J. and Morby, Andrew P. 2003. Characterisation of CadR from Pseudomonas aeruginosa: a Cd(II)-responsive MerR homologue. Biochemical and Biophysical Research Communications 308 (2) , pp. 234-239. 10.1016/S0006-291X(03)01366-4

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cadR from Pseudomonas aeruginosa encodes a transcriptional regulatory protein which responds to Cd(II)≫Zn(II)>Hg(II) at its cognate promoter PcadA. CadR will also act to induce transcription at the Escherichia coli ZntR cognate promoter, PzntA, however, the induction profile is altered to Hg(II)>Cd(II)>Zn(II). Two separate single base pair deletions within PzntA result in further alteration of relative specificity in metal-ion induction profile for CadR. This demonstrates that the operator/promoter sequence can play a role in defining optimal ligand response and that for these regulators specificity is not solely a function of the regulatory protein.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Publisher: Elsevier
ISSN: 0006-291X
Last Modified: 04 Jun 2017 06:37

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