Baudouin, Stephane J. ORCID: https://orcid.org/0000-0001-6902-6071, Pujol, Fabien, Nicot, Arnaud, Kitabgi, Patrick and Boudin, Hélène 2006. Dendrite-selective redistribution of the chemokine receptor CXCR4 following agonist stimulation. Molecular and Cellular Neuroscience 33 (2) , pp. 160-169. 10.1016/j.mcn.2006.07.007 |
Abstract
The chemokine SDF-1 is a secreted protein that plays a critical role in several aspects of neuron development through interaction with its unique receptor CXCR4. A key mechanism that controls neuron responsiveness to extracellular signals during neuronal growth is receptor endocytosis. Since we previously reported that SDF-1 regulates axon development without affecting the other neurites, we asked whether this could correlate with a compartment-selective trafficking of CXCR4. We thus studied CXCR4 behavior upon SDF-1 exposure in rat hippocampus slices and in transfected neuron cultures. A massive agonist-induced redistribution of CXCR4 in endosomes was observed in dendrites whereas no modification was evidenced in axons. Our data suggest that CXCR4 trafficking may play a role in mediating selective effects of SDF-1 on distinct neuronal membrane subdomains.
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | Biosciences |
Subjects: | Q Science > QH Natural history Q Science > QH Natural history > QH426 Genetics |
Uncontrolled Keywords: | Trafficking; Endocytosis; Hippocampal neuron; Chemokine; Development; G-protein-coupled receptor |
Publisher: | Elsevier |
ISSN: | 1044-7431 |
Last Modified: | 10 Feb 2024 02:16 |
URI: | https://orca.cardiff.ac.uk/id/eprint/62305 |
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