Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms

Andorfer, Cathy, Kress, Yvonne, Espinoza, Marisol, De Silva, Rohan, Tucker, Kerry L., Barde, Yves-Alain ORCID: https://orcid.org/0000-0002-7627-461X, Duff, Karen and Davies, Peter 2003. Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms. Journal of Neurochemistry 86 (3) , pp. 582-590. 10.1046/j.1471-4159.2003.01879.x

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Abstract

Neurofibrillary tangles are composed of insoluble aggregates of the microtubule-associated protein tau. In Alzheimer's disease the accumulation of neurofibrillary tangles occurs in the absence of tau mutations. Here we present mice that develop pathology from non-mutant human tau, in the absence of other exogenous factors, including β-amyloid. The pathology in these mice is Alzheimer-like, with hyperphosphorylated tau accumulating as aggregated paired helical filaments. This pathologic tau accumulates in the cell bodies and dendrites of neurons in a spatiotemporally relevant distribution.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences
ISSN:	0022-3042
Last Modified:	27 Oct 2022 08:26
URI:	https://orca.cardiff.ac.uk/id/eprint/62299

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