Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

The molecular genetic analysis of haemophilia A; characterization of six partial deletions in the factor VIII gene

Millar, D. S., Steinbrecher, R. A., Wieland, K., Grundy, C. B., Martinowitz, U., Krawczak, M., Zoll, B., Whitmore, D., Stephenson, J., Mibashan, R. S., Kakkar, V. V. and Cooper, David Neil 1990. The molecular genetic analysis of haemophilia A; characterization of six partial deletions in the factor VIII gene. Human Genetics 86 (2) , pp. 219-227. 10.1007/BF00197709

Full text not available from this repository.

Abstract

In a survey of 528 unrelated haemophilia A patients, six partial deletions of the factor VIII (FVIII) gene were detected by Southern blotting. These deletions were further mapped by a combination of Southern blotting and polymerase chain reaction amplification and found to vary in length between 4.7kb and 57kb. The frequency of detectable FVIII gene deletions (about 1%) is thus considerably lower than previously reported. Statistical analysis of currently available data did not provide any evidence for a deletion “hotspot”. Four of the six deletion patients reported here possessed inhibitors. Taken together with previous data, deletion of the FVIII gene was found to be associated with an approximately fivefold higher risk of developing inhibitors compared with other severe haemophiliacs without gene deletions.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Publisher: Springer
ISSN: 0340-6717
Last Modified: 04 Jun 2017 06:33
URI: http://orca-mwe.cf.ac.uk/id/eprint/62048

Citation Data

Cited 37 times in Google Scholar. View in Google Scholar

Cited 36 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item