Hughes, Colan E., Williams, P. Andrew and Harris, Kenneth D. M.
2014.
"Classic NMR": an in-situ NMR strategy for mapping the time-evolution of crystallization processes by combined liquid-state and solid-state measurements.
Angewandte Chemie International Edition
53
(34)
, pp. 8939-8943.
10.1002/anie.201404266
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Abstract
A new in-situ NMR strategy (termed CLASSIC NMR) for mapping the evolution of crystallization processes is reported, involving simultaneous measurement of both liquid-state and solid-state NMR spectra as a function of time. This combined strategy allows complementary information to be obtained on the evolution of both the solid and liquid phases during the crystallization process. In particular, as crystallization proceeds (monitored by solid-state NMR), the solution state becomes more dilute, leading to changes in solution-state speciation and the modes of molecular aggregation in solution, which are monitored by liquid-state NMR. The CLASSIC NMR experiment is applied here to yield new insights into the crystallization of m-aminobenzoic acid.
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | Chemistry |
Subjects: | Q Science > QD Chemistry |
Uncontrolled Keywords: | Crystal growth; in-situ studies; solid-state nmr spectroscopy; time-dependent processes. |
Publisher: | Wiley |
ISSN: | 1433-7851 |
Funders: | EPSRC, BBSRC |
Date of First Compliant Deposit: | 30 March 2016 |
Last Modified: | 14 Sep 2020 16:00 |
URI: | http://orca-mwe.cf.ac.uk/id/eprint/61648 |
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