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Mouse models with modified p53 sequences to study cancer and ageing [Review]

Clarke, Alan Richard ORCID: https://orcid.org/0000-0002-4281-426X and Hollstein, M. 2003. Mouse models with modified p53 sequences to study cancer and ageing [Review]. Cell Death and Differentiation 10 (4) , pp. 443-450. 10.1038/sj.cdd.4401188

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Abstract

periments with p53 transgenic and p53 gene-targeted mouse strains have substantiated, and in some cases challenged, a number of hypotheses on the biology of the p53 protein. New questions have emerged regarding similarities and differences between murine and human genetic networks in various tissues. Mouse models with targeted p53 alleles are now applied not only to investigate tumour susceptibility, but also to address questions pertinent to molecular epidemiology, chemoprevention, development of anticancer p53-specific pharmaceuticals, and ageing.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Subjects: Q Science > Q Science (General)
Uncontrolled Keywords: Transgenic; p53; Cre-Lox; ageing; neoplasia; murine.
Publisher: Nature Publishing Group
ISSN: 1350-9047
Last Modified: 25 Oct 2022 10:11
URI: https://orca.cardiff.ac.uk/id/eprint/61371

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