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Animal models of Parkinson's Disease

Lane, Emma Louise, Carlsson, Thomas, Kirik, Deniz and Dunnett, Stephen Bruce 2008. Animal models of Parkinson's Disease. In: Conn, P. Michael ed. 2008 Sourcebook of Models for Biomedical Research, Humana Press, pp. 313-322. (10.1007/978-1-59745-285-4_34)

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Abstract

Parkinson’s disease is a movement disorder, caused predominantly by the degeneration of the dopaminergic nigrostriatal pathway. Various animal models have been developed in both rodents and nonhuman primates that have been used successfully in the evaluation of pharmacotherapeutics. The most commonly used animal models are generated through the administration of toxins; those most extensively characterized with a view to analyzing motor deficits are the 6-hydroxydopamine (6-OHDA) lesioned rat and the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated nonhuman primate. We review how these models are developed and the most common behavioral tests used to discern motor impairments and the improvements afforded by both pharmacological and surgical interventions. A major problem in the treatment of Parkinson’s disease is the generation of dyskinesia, or abnormal involuntary movements following the long-term administration of l-DOPA. Until recently, research on dyskinesia was restricted to the use of the MPTP-treated nonhuman primate, but the development of a rodent model has improved understanding of the mechanisms responsible and expedited screening of drugs for their dyskinesiogenic potential. Although both rodent and nonhuman primate models have significantly furthered our understanding of the mechanisms behind Parkinson’s disease and the associated motor complications, both still have significant limitations. Therefore, the search continues for a model that can reproduce not just the neuropathology and symptoms of the disease, but also recreate more faithfully the progressive pathogenic aspects of the disease.

Item Type: Book Section
Date Type: Publication
Status: Published
Schools: Pharmacy
Subjects: R Medicine > RS Pharmacy and materia medica
Publisher: Humana Press
ISBN: 9781588299338
Last Modified: 16 Apr 2019 20:23
URI: http://orca-mwe.cf.ac.uk/id/eprint/60810

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