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Haemostatic and fibrinolytic responses to bone marrow transplantation

Brown, S. A., Davies, S. V., Fegan, Christopher Daniel, West, Robert Raynard, Giddings, J., Whittaker, J. and Burnett, Alan Kenneth 1999. Haemostatic and fibrinolytic responses to bone marrow transplantation. British Journal of Haematology 104 (3) , pp. 468-474. 10.1046/j.1365-2141.1999.01223.x

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Abstract

Thrombin and plasmin activation markers were serially measured in 80 patients undergoing bone marrow transplantation (BMT). There were prothrombotic and fibrinolytic responses observed during autograft and allograft BMTs. Thrombin-antithrombin and prothrombin fragment F1+2 levels increased from day -7 to -3 (P<0.0001) from 3.7 to 7 ng/ml and 1.2 to 1.63 nmol/l, respectively. A rise in plasmin-antiplasmin levels occurred between days 4 and 14 (P< 0.0004), from 393 ng/ml on day -7 to a peak of 795 ng/ml on day 11. No correlation between reduced protein C levels post-BMT and a prothrombotic state was observed.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
R Medicine > RZ Other systems of medicine
Uncontrolled Keywords: bone marrow transplantation; prothrombotic state; fibrinolysis; protein C
Publisher: Wiley-Blackwell
ISSN: 0007-1048
Last Modified: 25 Jun 2017 04:42
URI: http://orca-mwe.cf.ac.uk/id/eprint/58975

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