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N-Heterocyclic carbenes/imidazolium salts as substrates in catalysis: the catalytic 2-substitution and annulation of heterocyclic compounds

Cavell, Kingsley John 2008. N-Heterocyclic carbenes/imidazolium salts as substrates in catalysis: the catalytic 2-substitution and annulation of heterocyclic compounds. Dalton Transactions (47) , pp. 6676-6685. 10.1039/b811449h

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Abstract

N-Heterocyclic carbenes (NHCs) are commonly regarded as strong donor ligands that are valuable in coordination chemistry and catalysis. Many reports describing this aspect of their chemistry have been published. The alternative view of NHCs as reaction intermediates has been little explored, and yet excellent examples exist and will be reviewed in this perspective. Group 10 hydrocarbyl complexes of NHCs [(R)(NHC)ML2 where R = H, alkyl, aryl, acyl; M = Ni, Pd, Pt] undergo a facile reductive elimination to generate M(0) and R-substituted-azolium salt as products. On the other hand, 2-Hazolium salts will oxidatively add to M(0) complexes to afford reactive NHC–M–H compounds, suitable as catalysts for selected reactions. Combining the oxidative addition and reductive elimination steps into a single cycle, in the presence of an alkene, provides of a novel and potentially exciting, atom efficient catalytic C–C bond forming process for the substitution, and annulation of heterocyclic rings.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Chemistry
Cardiff Catalysis Institute (CCI)
Subjects: Q Science > QD Chemistry
Publisher: RSC
ISSN: 1477-9226
Last Modified: 19 Mar 2016 22:09
URI: https://orca.cardiff.ac.uk/id/eprint/5890

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