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Poxvirus homologues of cellular genes

Bugert, Joachim Jakob ORCID: https://orcid.org/0000-0002-0556-3211 and Darai, G. 2000. Poxvirus homologues of cellular genes. Virus Genes 21 (1-2) , pp. 111-133. 10.1023/A:1008140615106

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Abstract

Over the course of time poxviruses have acquired or “captured” numerous homologues of cellular genes and incorporated them into their large DNA genomes. With more poxvirus genome sequencing data becoming available, the number of newly discovered poxviral cellular homologues is constantly increasing. A common feature of these genes is that they are nonessential for virus replication in vitro and they confer selective advantages in dealing with host cell differentiation and immune defense mechanisms in vivo. Poxviral cellular homologues are reviewed in this synopsis considering the specific viral habitats of different poxviruses and the immune defence capabilities of their respective hosts. Possible mechanisms of cellular gene acquisition by poxviruses as suggested by the analysis of mobile genetic elements in large DNA viruses are discussed. The investigation of poxvirus homologues of cellular genes is essential for our understanding of the mechanisms that regulate virus/host interactions on the cellular level and the host response against infection.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Uncontrolled Keywords: Animals, Humans, Molecular Mimicry, Poxviridae/genetics, Poxviridae/pathogenicity, Poxviridae Infections/immunology, Poxviridae Infections/virology, Viral Proteins/chemistry, Viral Proteins/genetics, Viral Proteins/physiology
Publisher: Springer Verlag
ISSN: 0920-8569
Last Modified: 25 Oct 2022 09:20
URI: https://orca.cardiff.ac.uk/id/eprint/58122

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