CAG repeat length in the hKCa3 gene and symptom dimensions in schizophrenia

Cardno, Alastair G., Bowen, Timothy, Guy, Carol, Jones, Lisa A., McCarthy, Geraldine, Williams, Nigel Melville, Murphy, Kieran C., Spurlock, Gillian, Gray, Marion, Sanders, Rebecca, Craddock, Nicholas John, McGuffin, Peter, Owen, Michael John and O'Donovan, Michael Conlon 1999. CAG repeat length in the hKCa3 gene and symptom dimensions in schizophrenia. Biological Psychiatry 45 (12) , pp. 1592-1596. 10.1016/s0006-3223(99)00033-5

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Abstract

BACKGROUND: Long CAG repeats in the hKCa3 potassium channel gene have been associated with schizophrenia. We sought evidence for associations between this polymorphism and aspects of the schizophrenia phenotype. METHODS: Associations were investigated between CAG repeat length and gender, age of illness onset, and psychotic symptom dimensions in 203 unrelated individuals with DSM-IIIR schizophrenia. RESULTS: No association was found between CAG repeat length and gender or age of onset. Long CAG repeats were associated with higher negative symptom dimension scores. CONCLUSIONS: This study provides preliminary evidence that genetic liability to negative symptoms in schizophrenia may be partly mediated through the hKCa3 gene.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords:	Potassium channel; trinucleotide repeats; schizophrenia; association; negative symptoms
Publisher:	Elsevier
ISSN:	0006-3223
Last Modified:	25 Sep 2019 02:15
URI:	http://orca-mwe.cf.ac.uk/id/eprint/57951

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