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Does phenylethylamine have a role in schizophrenia?: LSD and PCP up-regulate aromatic l-amino acid decarboxylase mRNA levels

Buckland, Paul Robert, Marshall, Rupert, Watkins, Peter and McGuffin, Peter 1997. Does phenylethylamine have a role in schizophrenia?: LSD and PCP up-regulate aromatic l-amino acid decarboxylase mRNA levels. Molecular Brain Research 49 (1-2) , pp. 266-270. 10.1016/S0169-328X(97)00160-5

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Abstract

Aromatic l-amino acid decarboxylase (AADC) is rate limiting in the production of 2-phenylethylamine (2PE). AADC activity and 2PE serum concentrations have been found to be increased in schizophrenic patients. Both antipsychotic and psychotogenic drugs, including amphetamine, affect the activity and encoding mRNA levels of AADC. Amphetamine is an analogue of 2PE and has a similar physiological effect. We have looked at the effects of chronic (32 day) treatment of rats with LSD (0.12 μg/kg/day) and phencyclidine (PCP; 10 mg/kg/day) on AADC mRNA levels. Both drugs up-regulated AADC mRNA levels in striatum, nucleus accumbens, hippocampus and cerebellum by between 50% and 150%. A splicing variant of AADC, present in human brain, which lacks the 3rd exon does not appear to be present in rat brain. These results are consistent with the hypothesis that over activity of AADC leading to increased production of 2PE is involved in endogenous psychosis such as schizophrenia.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Subjects: R Medicine > R Medicine (General)
Publisher: Elsevier
ISSN: 0169-328X
Last Modified: 04 Jun 2017 06:16
URI: http://orca-mwe.cf.ac.uk/id/eprint/57896

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