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Psychopathology and cognition in children with 22q11.2 deletion syndrome

Niarchou, Maria, Zammit, Stanley, van Goozen, Stephanie Helena Maria, Thapar, Anita, Tierling, Hayley, Owen, Michael John and van den Bree, Marianne Bernadette 2014. Psychopathology and cognition in children with 22q11.2 deletion syndrome. British Journal of Psychiatry 204 (1) , pp. 46-54. 10.1192/bjp.bp.113.132324

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Abstract

BACKGROUND: Children with 22q11.2 deletion syndrome (22q11.2DS) have been reported to have high rates of cognitive and psychiatric problems. AIMS: To establish the nature and prevalence of psychiatric disorder and neurocognitive impairment in children with 22q11.2DS and test whether risk of psychopathology is mediated by the children's intellectual impairment. METHOD: Neurocognition and psychopathology were assessed in 80 children with 22q11.2DS (mean age 10.2 years, s.d. = 2.1) and 39 sibling controls (mean age 10.9 years, s.d. = 2.0). RESULTS: More than half (54%) of children with 22q11.2DS met diagnostic criteria for one or more DSM-IV-TR psychiatric disorder. These children had lower IQ (mean 76.8, s.d. = 13.0) than controls (mean 108.6, s.d. = 15.2) (P<0.001) and showed a range of neurocognitive impairments. Increased risk of psychopathology was not mediated by intellectual impairment. CONCLUSIONS: 22q11.2DS is not related to a specific psychiatric phenotype in children. Moreover, the deletion has largely independent effects on IQ and risk of psychopathology, indicating that psychopathology in 22q11.2DS is not a non-specific consequence of generalised cognitive impairment.

Item Type: Article
Date Type: Publication
Status: Published
Schools: MRC Centre for Neuropsychiatric Genetics and Genomics
Medicine
Psychology
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: B Philosophy. Psychology. Religion > BF Psychology
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher: Royal College of Psychiatrists
ISSN: 0007-1250
Funders: Wellcome Trust
Last Modified: 20 Oct 2017 18:49
URI: http://orca-mwe.cf.ac.uk/id/eprint/57778

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Cited 10 times in Web of Science. View in Web of Science.

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