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Both splicing variants of the dopamine D2 receptor mRNA are up-regulated by antipsychotic drugs

Buckland, Paul Robert, O'Donovan, Michael Conlon and McGuffin, Peter 1993. Both splicing variants of the dopamine D2 receptor mRNA are up-regulated by antipsychotic drugs. Neuroscience Letters 150 (1) , pp. 25-28. 10.1016/0304-3940(93)90099-7

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Abstract

We have investigated the effects of antipsychotic drugs on the expression of the two dopamine D2 receptor splicing variants using multiprobe oligonucleotide solution hybridisation. Both long and short mRNA variants were increased in abundance by approximately 2-fold by both haloperidol and loxapine after 32 days drug administration.

Item Type: Article
Date Type: Publication
Status: Published
Schools: MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Medicine
Subjects: R Medicine > R Medicine (General)
Uncontrolled Keywords: Dopamine D2 gene expression; Messenger RNA measurement; Alternative splicing; Antipsychotic; Solution hybridisation
Publisher: Elsevier
ISSN: 0304-3940
Last Modified: 04 Jun 2017 06:15
URI: http://orca-mwe.cf.ac.uk/id/eprint/57738

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